Cushing Syndrome Cardiomyopathy

Endogenous Cushing syndrome (CS) is associated with systemic manifestations including abnormalities in glucose and lipid metabolism, alterations in coagulation factors, hypertension, cardiovascular disease, depression, and impaired health-related quality of life.Dilated cardiomyopathy is rarely associated with CS, with only few single cases previously reported in English literature.1 Histological changes and molecular pathways involved in CS-dilated cardiomyopathy are poorly understood, whereas structural outcome after cardiac recovery is unknown.We reported a research case of CS dilated cardiomyopathy in which noninvasive and invasive cardiac studies at baseline and follow-up were obtained after written patient consent.A 63-year-old woman had CS caused by adrenal adenoma. Echocardiographic left ventricular (LV) end-diastolic diameter, ejection fraction and maximal wall thickness, endomyocardial biopsy with assessment of cardiomyocyte diameter, % myofibrillolysis area, myocardial fibrosis and cell death, and myocardial atrogin-1 were evaluated at presentation and after 1-year cortisol normalization with adrenalectomy. At presentation, …