Targeted Transthoracic Acoustic Activation of Systemically Administered Nanodroplets to Detect Myocardial Perfusion Abnormalities | Zendy

Thomas R. Porter | Zendy; Christopher B. Arena | Zendy; Samer Sayyed | Zendy; John Lof | Zendy; Robin High | Zendy; Feng Xie | Zendy; Paul A. Dayton | Zendy

Open Access

Targeted Transthoracic Acoustic Activation of Systemically Administered Nanodroplets to Detect Myocardial Perfusion Abnormalities

Author(s) -

Thomas R. Porter,

Christopher B. Arena,

Samer Sayyed,

John Lof,

Robin High,

Feng Xie,

Paul A. Dayton

Publication year - 2015

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.115.003770

Subject(s) - mechanical index , magnetic resonance imaging , ultrasound , perfusion , core (optical fiber) , myocardial perfusion imaging , medicine , myocardial infarction , mri contrast agent , clinical imaging , biomedical engineering , microbubbles , cardiology , materials science , radiology , composite material

Liquid core nanodroplets containing condensed gaseous fluorocarbons can be vaporized at clinically relevant acoustic energies and have been hypothesized as an alternative ultrasound contrast agent instead of gas-core agents. The potential for targeted activation and imaging of these agents was tested with droplets formulated from liquid octafluoropropane (C3) and 1:1 mixtures of C3 with liquid decafluorobutane (C3C4).

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