Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm | Zendy

Reza Golestani | Zendy; Mahmoud Razavian | Zendy; Lei Nie | Zendy; Jiasheng Zhang | Zendy; Jae-Joon Jung | Zendy; Yunpeng Ye | Zendy; Michelle de Roo | Zendy; Koen Hilgerink | Zendy; Chi Liu | Zendy; Simon P. Robinson | Zendy; Mehran M. Sadeghi | Zendy

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Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm

Author(s) -

Reza Golestani,

Mahmoud Razavian,

Lei Nie,

Jiasheng Zhang,

Jae-Joon Jung,

Yunpeng Ye,

Michelle de Roo,

Koen Hilgerink,

Chi Liu,

Simon P. Robinson,

Mehran M. Sadeghi

Publication year - 2014

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.114.002471

Subject(s) - medicine , abdominal aortic aneurysm , aorta , aneurysm , angiotensin ii , matrix metalloproteinase , abdominal aorta , aortic aneurysm , aortic rupture , in vivo , pathology , radiology , nuclear medicine , biology , microbiology and biotechnology , blood pressure

Abdominal aortic aneurysm (AAA) rupture risk is currently determined based on size and symptoms. This approach does not address the rupture risk associated with small aneurysms. Given the role of matrix metalloproteinases (MMPs) in AAA weakening and rupture, we investigated the potential of MMP-targeted imaging for detection of aneurysm biology and prediction of outcome in a mouse model of AAA with spontaneous rupture.

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