Open AccessPrediction of Sarcomere Mutations in Subclinical Hypertrophic Cardiomyopathy
Author(s) -
Gabriella Captur,
Luís R. Lopes,
Timothy J. Mohun,
Vimal Patel,
Chunming Li,
Paul Bassett,
Gherardo Finocchiaro,
Vanessa M. Ferreira,
Maite Tome,
Vivek Muthurangu,
Mark V. Sherrid,
Sharlene M. Day,
Charles E. Canter,
William J. McKenna,
Christine E. Seidman,
David A. Bluemke,
Perry Elliott,
Carolyn Y. Ho,
James Moon
Publication year - 2014
Publication title -
circulation cardiovascular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.584
H-Index - 99
eISSN - 1942-0080
pISSN - 1941-9651
DOI - 10.1161/circimaging.114.002411
Subject(s) - medicine , hypertrophic cardiomyopathy , sarcomere , subclinical infection , cardiology , cardiomyopathy , heart failure , myocyte
Sarcomere protein mutations in hypertrophic cardiomyopathy induce subtle cardiac structural changes before the development of left ventricular hypertrophy (LVH). We have proposed that myocardial crypts are part of this phenotype and independently associated with the presence of sarcomere gene mutations. We tested this hypothesis in genetic hypertrophic cardiomyopathy pre-LVH (genotype positive, LVH negative [G+LVH-]).
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