In Vivo Molecular Imaging of Thrombosis and Thrombolysis Using a Fibrin-Binding Positron Emission Tomographic Probe | Zendy

İlknur Ay | Zendy; Francesco Blasi | Zendy; Tyson A. Rietz | Zendy; Nicholas J. Rotile | Zendy; Sreekanth Kura | Zendy; A.-L. Brownell | Zendy; Helen Day | Zendy; Bruno L. Oliveira | Zendy; Richard J. Looby | Zendy; Peter Caravan | Zendy

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In Vivo Molecular Imaging of Thrombosis and Thrombolysis Using a Fibrin-Binding Positron Emission Tomographic Probe

Author(s) -

İlknur Ay,

Francesco Blasi,

Tyson A. Rietz,

Nicholas J. Rotile,

Sreekanth Kura,

A.-L. Brownell,

Helen Day,

Bruno L. Oliveira,

Richard J. Looby,

Peter Caravan

Publication year - 2014

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.113.001806

Subject(s) - biodistribution , thrombus , medicine , ex vivo , positron emission tomography , fibrin , thrombosis , plasminogen activator , pathology , nuclear medicine , in vivo , radiology , biology , immunology , microbiology and biotechnology

Fibrin is a major component of arterial and venous thrombi and represents an ideal candidate for molecular imaging of thrombosis. Here, we describe imaging properties and target uptake of a new fibrin-specific positron emission tomographic probe for thrombus detection and therapy monitoring in 2 rat thrombosis models.

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