Noninvasive Assessment of Hypoxia in Rabbit Advanced Atherosclerosis Using 18 F-fluoromisonidazole Positron Emission Tomographic Imaging | Zendy

Jesús Mateo | Zendy; David IzquierdoGarcia | Zendy; Juan J. Badimon | Zendy; Zahi A. Fayad | Zendy; Valentı́n Fuster | Zendy

Open Access

Noninvasive Assessment of Hypoxia in Rabbit Advanced Atherosclerosis Using ¹⁸ F-fluoromisonidazole Positron Emission Tomographic Imaging

Author(s) -

Jesús Mateo,

David IzquierdoGarcia,

Juan J. Badimon,

Zahi A. Fayad,

Valentı́n Fuster

Publication year - 2014

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.113.001084

Subject(s) - hypoxia (environmental) , positron emission tomography , neovascularization , fluorodeoxyglucose , pathology , standardized uptake value , medicine , immunohistochemistry , cd31 , aorta , nuclear medicine , angiogenesis , chemistry , organic chemistry , oxygen

Hypoxia is an important microenvironmental factor influencing atherosclerosis progression by inducing foam-cell formation, metabolic adaptation of infiltrated macrophages, and plaque neovascularization. Therefore, imaging plaque hypoxia could serve as a marker of lesions at risk.

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