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Hypoxia is an important microenvironmental factor influencing atherosclerosis progression by inducing foam-cell formation, metabolic adaptation of infiltrated macrophages, and plaque neovascularization. Therefore, imaging plaque hypoxia could serve as a marker of lesions at risk.

Noninvasive Assessment of Hypoxia in Rabbit Advanced Atherosclerosis Using 18 F-fluoromisonidazole Positron Emission Tomographic Imaging

Noninvasive Assessment of Hypoxia in Rabbit Advanced Atherosclerosis Using ¹⁸ F-fluoromisonidazole Positron Emission Tomographic Imaging