Sample Size and Cost Analysis for Pulmonary Arterial Hypertension Drug Trials Using Various Imaging Modalities to Assess Right Ventricular Size and Function End Points | Zendy

Karima Addetia | Zendy; Nicole M. Bhave | Zendy; Corey E. Tabit | Zendy; Mardi GombergMaitland | Zendy; Benjamin H. Freed | Zendy; Karin E. Dill | Zendy; Roberto M. Lang | Zendy; Victor MorAvi | Zendy; Amit R. Patel | Zendy

Open Access

Sample Size and Cost Analysis for Pulmonary Arterial Hypertension Drug Trials Using Various Imaging Modalities to Assess Right Ventricular Size and Function End Points

Author(s) -

Karima Addetia,

Nicole M. Bhave,

Corey E. Tabit,

Mardi GombergMaitland,

Benjamin H. Freed,

Karin E. Dill,

Roberto M. Lang,

Victor MorAvi,

Amit R. Patel

Publication year - 2013

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.113.000932

Subject(s) - medicine , ventricle , cardiology , sample size determination , ejection fraction , pulmonary hypertension , placebo , diastole , clinical trial , blood pressure , heart failure , statistics , pathology , alternative medicine , mathematics

Placebo-controlled trials for pulmonary arterial hypertension are no longer acceptable because new therapies must show clinically significant effects on top of standard treatment. The purpose of this study was to estimate sample sizes and imaging costs for the planning of a hypothetical pulmonary arterial hypertension drug trial using imaging to detect changes in right ventricular size and function in response to combined therapy.

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