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That left ventricular growth occurs in response to exercise is, of course, well known. This relates to the increase in cardiac work, in turn a function of increased volume and pressure loading. As such, variation in the left ventricular hypertrophic response to exercise will result from differences in the external work undertaken, the cardiac work performed to deliver this work (the environmental stimulus to growth), and the genetic background of each individual.1 As such, we do not doubt …

circulation. cardiovascular imaging

Response to Letter About Article, “Left Ventricular Wall Thickness and the Presence of Asymmetric Hypertrophy in Healthy Young Army Recruits: Data From the LARGE Heart Study”