Role of Transcytolemmal Water-Exchange in Magnetic Resonance Measurements of Diffuse Myocardial Fibrosis in Hypertensive Heart Disease | Zendy

Otávio R. CoelhoFilho | Zendy; FrançoisPierre Mongeon | Zendy; Richard N. Mitchell | Zendy; Heitor Moreno | Zendy; Wilson Nadruz | Zendy; Raymond Y. Kwong | Zendy; Michael JeroschHerold | Zendy

Open Access

Role of Transcytolemmal Water-Exchange in Magnetic Resonance Measurements of Diffuse Myocardial Fibrosis in Hypertensive Heart Disease

Author(s) -

Otávio R. CoelhoFilho,

FrançoisPierre Mongeon,

Richard N. Mitchell,

Heitor Moreno,

Wilson Nadruz,

Raymond Y. Kwong,

Michael JeroschHerold

Publication year - 2012

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.112.979815

Subject(s) - medicine , fibrosis , connective tissue , myocardial fibrosis , magnetic resonance imaging , cardiology , muscle hypertrophy , extracellular fluid , pathology , extracellular , chemistry , radiology , biochemistry

The myocardial extracellular volume fraction (MECVF) has been used to detect diffuse fibrosis. Estimation of MECVF relies on quantification of the T1 relaxation time after contrast enhancement, which can be sensitive to equilibrium transcytolemmal water-exchange. We hypothesized that MECVF, quantified with a parsimonious 2-space water-exchange model, correlates positively with the connective tissue volume fraction in a rodent model of hypertensive heart disease, whereas the widely used analysis based on assuming fast transcytolemmal water-exchange could result in a significant underestimate of MECVF.

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