In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice | Zendy

David M. Baron | Zendy; Maëva Clerté | Zendy; Peter Brouckaert | Zendy; Michael J. Raher | Zendy; Aidan Flynn | Zendy; Haihua Zhang | Zendy; Edward A. Carter | Zendy; Michael H. Picard | Zendy; Kenneth D. Bloch | Zendy; Emmanuel S. Buys | Zendy; Marielle ScherrerCrosbie | Zendy

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In Vivo Noninvasive Characterization of Brown Adipose Tissue Blood Flow by Contrast Ultrasound in Mice

Author(s) -

David M. Baron,

Maëva Clerté,

Peter Brouckaert,

Michael J. Raher,

Aidan Flynn,

Haihua Zhang,

Edward A. Carter,

Michael H. Picard,

Kenneth D. Bloch,

Emmanuel S. Buys,

Marielle ScherrerCrosbie

Publication year - 2012

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.112.975607

Subject(s) - brown adipose tissue , blood flow , nitric oxide , norepinephrine , endocrinology , medicine , nitric oxide synthase , biology , stimulation , adipose tissue , blood pressure , thermogenin , chemistry , dopamine

Interventions to increase brown adipose tissue (BAT) volume and activation are being extensively investigated as therapies to decrease the body weight in obese subjects. Noninvasive methods to monitor these therapies in animal models and humans are rare. We investigated whether contrast ultrasound (CU) performed in mice could detect BAT and measure its activation by monitoring BAT blood flow. After validation, CU was used to study the role of uncoupling protein 1 and nitric oxide synthases in the acute regulation of BAT blood flow.

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