Cardiac-Selective Expression of Extracellular Superoxide Dismutase After Systemic Injection of Adeno-Associated Virus 9 Protects the Heart Against Post–Myocardial Infarction Left Ventricular Remodeling | Zendy

Prasad Konkalmatt | Zendy; Ronald J. Beyers | Zendy; Daniel O’Connor | Zendy; Yaqin Xu | Zendy; Marc E. Seaman | Zendy; Brent A. French | Zendy

Open Access

Cardiac-Selective Expression of Extracellular Superoxide Dismutase After Systemic Injection of Adeno-Associated Virus 9 Protects the Heart Against Post–Myocardial Infarction Left Ventricular Remodeling

Author(s) -

Prasad Konkalmatt,

Ronald J. Beyers,

Daniel O’Connor,

Yaqin Xu,

Marc E. Seaman,

Brent A. French

Publication year - 2013

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.112.000320

Subject(s) - myocardial infarction , ventricular remodeling , medicine , troponin complex , gene expression , cardiology , heart failure , reporter gene , troponin i , biology , gene , biochemistry

Cardiac magnetic resonance imaging has not been used previously to document the attenuation of left ventricular (LV) remodeling after systemic gene delivery. We hypothesized that targeted expression of extracellular superoxide dismutase (EcSOD) via the cardiac troponin-T promoter would protect the mouse heart against both myocardial infarction (MI) and subsequent LV remodeling.

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