Comprehensive Validation of Cardiovascular Magnetic Resonance Techniques for the Assessment of Myocardial Extracellular Volume | Zendy

Chris Miller | Zendy; Josephine H. Naish | Zendy; Paul Bishop | Zendy; Glyn A. Coutts | Zendy; David Clark | Zendy; Sha Zhao | Zendy; Simon Ray | Zendy; Nizar Yonan | Zendy; Simon G. Williams | Zendy; Andrew Flett | Zendy; James Moon | Zendy; Andreas Greiser | Zendy; Geoff J.M. Parker | Zendy; Matthias Schmitt | Zendy

Open Access

Comprehensive Validation of Cardiovascular Magnetic Resonance Techniques for the Assessment of Myocardial Extracellular Volume

Author(s) -

Chris Miller,

Josephine H. Naish,

Paul Bishop,

Glyn A. Coutts,

David Clark,

Sha Zhao,

Simon Ray,

Nizar Yonan,

Simon G. Williams,

Andrew Flett,

James Moon,

Andreas Greiser,

Geoff J.M. Parker,

Matthias Schmitt

Publication year - 2013

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.112.000192

Subject(s) - medicine , cardiac magnetic resonance , magnetic resonance imaging , cardiology , extracellular , extracellular fluid , volume (thermodynamics) , radiology , physics , quantum mechanics , biology , microbiology and biotechnology

Extracellular matrix expansion is a key element of ventricular remodeling and a potential therapeutic target. Cardiovascular magnetic resonance (CMR) T1-mapping techniques are increasingly used to evaluate myocardial extracellular volume (ECV); however, the most widely applied methods are without histological validation. Our aim was to perform comprehensive validation of (1) dynamic-equilibrium CMR (DynEq-CMR), where ECV is quantified using hematocrit-adjusted myocardial and blood T1 values measured before and after gadolinium bolus; and (2) isolated measurement of myocardial T1, used as an ECV surrogate.

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