Open AccessRegions of Low Endothelial Shear Stress Colocalize With Positive Vascular Remodeling and Atherosclerotic Plaque Disruption
Author(s) -
Alkystis Phinikaridou,
Ning Hua,
Tuan Anh Pham,
James A. Hamilton
Publication year - 2013
Publication title -
circulation cardiovascular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.584
H-Index - 99
eISSN - 1942-0080
pISSN - 1941-9651
DOI - 10.1161/circimaging.112.000176
Subject(s) - thrombus , fibrous cap , medicine , stenosis , inflammation , pathology , cardiology , chemistry
Local hemodynamic factors, particularly low endothelial shear stress (ESS), play a role in the focal formation of atherosclerosis. We used in vivo MRI to investigate the role of the magnitude of ESS on vascular remodeling, plaque burden, and disruption using a rabbit model of controlled atherothrombosis.
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