In Vivo Magnetization Transfer and Diffusion-Weighted Magnetic Resonance Imaging Detects Thrombus Composition in a Mouse Model of Deep Vein Thrombosis
Author(s) -
Alkystis Phinikaridou,
Marcelo E. Andía,
Prakash Saha,
Bijan Modarai,
Alberto Smith,
René M. Botnar
Publication year - 2013
Publication title -
circulation cardiovascular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.584
H-Index - 99
eISSN - 1942-0080
pISSN - 1941-9651
DOI - 10.1161/circimaging.112.000077
Subject(s) - thrombus , thrombosis , inferior vena cava , magnetic resonance imaging , deep vein , medicine , in vivo , effective diffusion coefficient , diffusion mri , pathology , radiology , nuclear medicine , nuclear magnetic resonance , biology , physics , microbiology and biotechnology
Deep vein thrombosis remains a major health problem necessitating accurate diagnosis. Thrombolysis is associated with significant morbidity and is effective only for the treatment of unorganized thrombus. We tested the feasibility of in vivo magnetization transfer (MT) and diffusion-weighted magnetic resonance imaging to detect thrombus organization in a murine model of deep vein thrombosis.
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