Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping | Zendy

Daniel Messroghli | Zendy; Sarah Nordmeyer | Zendy; Thore Dietrich | Zendy; Olaf Dirsch | Zendy; Elena Kaschina | Zendy; Kostas Savvatis | Zendy; Darach O h-Icí | Zendy; Christoph Klein | Zendy; Felix Berger | Zendy; Titus Küehne | Zendy

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Assessment of Diffuse Myocardial Fibrosis in Rats Using Small-Animal Look-Locker Inversion Recovery T1 Mapping

Author(s) -

Daniel Messroghli,

Sarah Nordmeyer,

Thore Dietrich,

Olaf Dirsch,

Elena Kaschina,

Kostas Savvatis,

Darach O h-Icí,

Christoph Klein,

Felix Berger,

Titus Küehne

Publication year - 2011

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.111.966796

Subject(s) - medicine , myocardial fibrosis , magnetic resonance imaging , fibrosis , multislice , cardiology , nuclear medicine , hematocrit , interquartile range , muscle hypertrophy , extracellular fluid , radiology , extracellular , chemistry , biochemistry

The concentration of gadopentetate dimeglumine in myocardium and blood can be assessed from T1 measurements and can be used to calculate the extracellular volume (ECV) of the myocardium. We hypothesized that diffuse myocardial fibrosis in a small-animal model could be quantitatively assessed by measuring myocardial ECV using small-animal Look-Locker inversion recovery T1 mapping.

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