Myocardial Uptake of 7′-(Z)-[ 123 I]Iodorotenone During Vasodilator Stress in Dogs With Critical Coronary Stenoses | Zendy

Alexis Broisat | Zendy; Mirta Ruiz | Zendy; Norman C. Goodman | Zendy; Stephen M. Hanrahan | Zendy; Bryan W. Reutter | Zendy; Kathleen Brennan | Zendy; Mustafa Janabi | Zendy; Saul Schaefer | Zendy; Denny D. Watson | Zendy; George Beller | Zendy; Henry F. VanBrocklin | Zendy; David K. Glover | Zendy

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Myocardial Uptake of 7′-(Z)-[ ¹²³ I]Iodorotenone During Vasodilator Stress in Dogs With Critical Coronary Stenoses

Author(s) -

Alexis Broisat,

Mirta Ruiz,

Norman C. Goodman,

Stephen M. Hanrahan,

Bryan W. Reutter,

Kathleen Brennan,

Mustafa Janabi,

Saul Schaefer,

Denny D. Watson,

George Beller,

Henry F. VanBrocklin,

David K. Glover

Publication year - 2011

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.110.961763

Subject(s) - perfusion , myocardial perfusion imaging , in vivo , thallium , biodistribution , medicine , single photon emission computed tomography , vasodilation , myocardial infarction , cardiology , blood flow , circumflex , nuclear medicine , chemistry , artery , inorganic chemistry , microbiology and biotechnology , biology

There is a well-recognized need for a new generation of single photon emission computed tomography (SPECT) perfusion tracers with improved myocardial extraction over a wide flow range. Radiotracers that target complex I of the mitochondrial electron transport chain have been proposed as a new class of myocardial perfusion imaging agents. 7-(Z)-[(125)I]iodorotenone ((125)I-ZIROT) has demonstrated superior myocardial extraction and retention characteristics in rats and in isolated perfused rabbit hearts. We sought to fully characterize the biodistribution and myocardial extraction versus flow relationship of (123)I-ZIROT in an intact large-animal model.

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