Heterogeneity of Intramural Function in Hypertrophic Cardiomyopathy | Zendy

Anthony H. Aletras | Zendy; Gauri S. Tilak | Zendy; LiYueh Hsu | Zendy; Andrew E. Arai | Zendy

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Heterogeneity of Intramural Function in Hypertrophic Cardiomyopathy

Author(s) -

Anthony H. Aletras,

Gauri S. Tilak,

LiYueh Hsu,

Andrew E. Arai

Publication year - 2011

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.110.958751

Subject(s) - hypertrophic cardiomyopathy , cardiology , medicine , function (biology) , cardiomyopathy , biology , heart failure , genetics

In hypertrophic cardiomyopathy (HCM), myocardial abnormalities are commonly heterogeneous. Two patterns of late gadolinium enhancement (LGE) have been reported: a bright "confluent" and an intermediate intensity abnormality termed "diffuse," each representing different degrees of myocardial scarring. We used MRI to study the relation between intramural cardiac function and the extent of fibrosis in HCM. The aim of this study was to determine whether excess collagen or myocardial scarring, as determined by LGE MRI, are the primary mechanisms leading to heterogeneous regional contractile function in patients with HCM.

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