Open AccessCarotid Atherosclerosis Progression in Familial Hypercholesterolemia Patients
Author(s) -
Menno Vergeer,
Rong Zhou,
Michiel L. Bots,
Raphaël Duivenvoorden,
Joerg Koglin,
Fatima Akdim,
Yale Mitchel,
Roeland Huijgen,
Aditi Sapre,
Eric de Groot,
Eric J.G. Sijbrands,
Richard C. Pasternak,
Claude Gagné,
Adéle Marais,
Christie M. Ballantyne,
Jonathan L. Isaacsohn,
Anton F. H. Stalenhoef,
John J.P. Kastelein
Publication year - 2010
Publication title -
circulation cardiovascular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.584
H-Index - 99
eISSN - 1942-0080
pISSN - 1941-9651
DOI - 10.1161/circimaging.109.909655
Subject(s) - medicine , simvastatin , statin , confidence interval , intima media thickness , randomized controlled trial , familial hypercholesterolemia , cardiology , cholesterol , carotid arteries
Until recently, patients with heterozygous familial hypercholesterolemia (HeFH) were considered the best subjects for the assessment of changes in carotid intima-media thickness (cIMT) in randomized intervention trials. Our aims were to investigate whether contemporary statin-treated HeFH patients still show accelerated cIMT increase and to assess the impact of statin treatment, before and after random assignment, on atherosclerosis progression.
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