Relationship Between Regional Myocardial Oxygenation and Perfusion in Patients With Coronary Artery Disease | Zendy

Theodoros D. Karamitsos | Zendy; Lucia Leccisotti | Zendy; Jayanth R. Arnold | Zendy; Alejandro RecioMayoral | Zendy; Paul BhamraAriza | Zendy; Ruairidh K Howells | Zendy; Nick Searle | Zendy; Matthew D. Robson | Zendy; Ornella Rimoldi | Zendy; Paolo G. Camici | Zendy; Stefan Neubauer | Zendy; Joseph B. Selvanayagam | Zendy

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Relationship Between Regional Myocardial Oxygenation and Perfusion in Patients With Coronary Artery Disease

Author(s) -

Theodoros D. Karamitsos,

Lucia Leccisotti,

Jayanth R. Arnold,

Alejandro RecioMayoral,

Paul BhamraAriza,

Ruairidh K Howells,

Nick Searle,

Matthew D. Robson,

Ornella Rimoldi,

Paolo G. Camici,

Stefan Neubauer,

Joseph B. Selvanayagam

Publication year - 2009

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.109.860148

Subject(s) - medicine , cardiology , coronary artery disease , perfusion , blood flow , ischemia , oxygenation , magnetic resonance imaging , stenosis , myocardial perfusion imaging , coronary circulation , blood oxygen level dependent , radiology

It is recognized that the interplay between myocardial ischemia, perfusion, and oxygenation in the setting of coronary artery disease (CAD) is complex and that myocardial oxygenation and perfusion may become dissociated. Blood oxygen level-dependent (BOLD) cardiovascular magnetic resonance (CMR) has the potential to noninvasively measure myocardial oxygenation, whereas positron emission tomography (PET) with oxygen-15 labeled water is the gold standard technique for myocardial blood flow quantification. Thus, we sought to apply BOLD CMR at 3 T and oxygen-15-labeled water PET in patients with CAD and normal volunteers to better understand the relationship between regional myocardial oxygenation and blood flow during vasodilator stress.

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