Open AccessMolecular MRI of Cardiomyocyte Apoptosis With Simultaneous Delayed-Enhancement MRI Distinguishes Apoptotic and Necrotic Myocytes In Vivo
Author(s) -
David E. Sosnovik,
Élisabeth Garanger,
Elena Aïkawa,
Matthias Nahrendorf,
Jose-Luiz Figuiredo,
Guangping Dai,
Fred Reynolds,
Anthony Rosenzweig,
Ralph Weissleder,
Lee Josephson
Publication year - 2009
Publication title -
circulation cardiovascular imaging
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.584
H-Index - 99
eISSN - 1942-0080
pISSN - 1941-9651
DOI - 10.1161/circimaging.109.859678
Subject(s) - apoptosis , in vivo , annexin , necrosis , gadolinium , chemistry , ischemia , magnetic resonance imaging , myocyte , annexin a5 , pathology , medicine , biology , biochemistry , radiology , microbiology and biotechnology , organic chemistry
A novel dual-contrast molecular MRI technique to image both cardiomyocyte apoptosis and necrosis in vivo within 4 to 6 hours of ischemia is presented. The technique uses the annexin-based nanoparticle AnxCLIO-Cy5.5 (apoptosis) and simultaneous delayed-enhancement imaging with a novel gadolinium chelate, Gd-DTPA-NBD (necrosis).
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