Development of Receptor for Advanced Glycation End Products–Directed Imaging of Atherosclerotic Plaque in a Murine Model of Spontaneous Atherosclerosis | Zendy

Yared Tekabe | Zendy; Qing Li | Zendy; Rosa Rosario | Zendy; Marija Sedlar | Zendy; Stan Majewski | Zendy; Barry I. Hudson | Zendy; Andrew J. Einstein | Zendy; Ann Marie Schmidt | Zendy; Lynne L. Johnson | Zendy

Open Access

Development of Receptor for Advanced Glycation End Products–Directed Imaging of Atherosclerotic Plaque in a Murine Model of Spontaneous Atherosclerosis

Author(s) -

Yared Tekabe,

Qing Li,

Rosa Rosario,

Marija Sedlar,

Stan Majewski,

Barry I. Hudson,

Andrew J. Einstein,

Ann Marie Schmidt,

Lynne L. Johnson

Publication year - 2008

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.108.788299

Subject(s) - rage (emotion) , medicine , glycation , aorta , pathology , apolipoprotein e , receptor , microbiology and biotechnology , biology , disease , neuroscience

The receptor for advanced glycation end products (RAGE) is implicated in the development and progression of atherosclerosis. We tested the hypothesis that (99m)Tc-labeled anti-RAGE F(ab')(2) can be used as a noninvasive tool to image atherosclerotic lesions in apolipoprotein E-deficient (apoE(-/-)) mice.

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