Myocardial Alterations in Senescent Mice and Effect of Exercise Training | Zendy

Geneviève Dérumeaux | Zendy; Fumito Ichinose | Zendy; Michael J. Raher | Zendy; John G. Morgan | Zendy; Téreza Coman | Zendy; Candace Lee | Zendy; Jose María Luzón Cuesta | Zendy; Hélène Thibault | Zendy; Kenneth D. Bloch | Zendy; Michael H. Picard | Zendy; Marielle ScherrerCrosbie | Zendy

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Myocardial Alterations in Senescent Mice and Effect of Exercise Training

Author(s) -

Geneviève Dérumeaux,

Fumito Ichinose,

Michael J. Raher,

John G. Morgan,

Téreza Coman,

Candace Lee,

Jose María Luzón Cuesta,

Hélène Thibault,

Kenneth D. Bloch,

Michael H. Picard,

Marielle ScherrerCrosbie

Publication year - 2008

Publication title -

circulation cardiovascular imaging

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.584

H-Index - 99

eISSN - 1942-0080

pISSN - 1941-9651

DOI - 10.1161/circimaging.107.745919

Subject(s) - medicine , cardiology , preload , contractility , fibrosis , hemodynamics , heart rate , myocardial fibrosis , strain (injury) , senescence , sirius red , diastole , blood pressure

Aging is accompanied by an alteration in myocardial contractility. However, its noninvasive detection is difficult. The effect of chronic exercise on this decrease is unknown. Murine models of senescence are increasingly used to test therapies in aging. We tested whether strain rate imaging detected left ventricular (LV) systolic dysfunction in aging mice and was able to assess a potential improvement after exercise.

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