Open AccessMendelian Randomization Studies Do Not Support a Role for Vitamin D in Coronary Artery Disease
Author(s) -
Despoina Manousaki,
Lauren E. Mokry,
Stephanie Ross,
David Goltzman,
J. Brent Richards
Publication year - 2016
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.116.001396
Subject(s) - mendelian randomization , coronary artery disease , odds ratio , medicine , single nucleotide polymorphism , vitamin d and neurology , population , genetics , biology , bioinformatics , gene , genotype , environmental health , genetic variants
Observational studies support a possible association between decreased vitamin D levels and risk of coronary artery disease (CAD); however, it remains unclear whether this relationship is causal. We aimed to evaluate whether genetically lowered vitamin D levels influence the risk of CAD using a Mendelian randomization approach.
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