Cardiac Disease Status Dictates Functional mRNA Targeting Profiles of Individual MicroRNAs | Zendy

Scot J. Matkovich | Zendy; Gerald W. Dorn | Zendy; Tiffani C. Grossenheider | Zendy; Peter Hecker | Zendy

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Cardiac Disease Status Dictates Functional mRNA Targeting Profiles of Individual MicroRNAs

Author(s) -

Scot J. Matkovich,

Gerald W. Dorn,

Tiffani C. Grossenheider,

Peter Hecker

Publication year - 2015

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.115.001237

Subject(s) - microrna , biology , gene silencing , transcriptome , argonaute , pressure overload , messenger rna , deep sequencing , microbiology and biotechnology , rna , bioinformatics , small interfering rna , gene expression , genetics , muscle hypertrophy , gene , endocrinology , cardiac hypertrophy , genome

MicroRNAs are key players in cardiac stress responses, but the mRNAs, whose abundance and translational potential are primarily affected by changes in cardiac microRNAs, are not well defined. Stimulus-induced, large-scale alterations in the cardiac transcriptome, together with consideration of the law of mass action, further suggest that the mRNAs most substantively targeted by individual microRNAs will vary between unstressed and stressed conditions. To test the hypothesis that microRNA target profiles differ in health and disease, we traced the fate of empirically determined miR-133a and miR-378 targets in mouse hearts undergoing pressure overload hypertrophy.

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