DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis | Zendy

Lindsay M. Reynolds | Zendy; Ma Wan | Zendy; Jingzhong Ding | Zendy; Jackson Taylor | Zendy; Kurt Lohman | Zendy; Dan Su | Zendy; Brian D. Bennett | Zendy; Devin K. Porter | Zendy; Ryan C. Gimple | Zendy; Gary S. Pittman | Zendy; Xuting Wang | Zendy; Timothy D. Howard | Zendy; David S. Siscovick | Zendy; Bruce M. Psaty | Zendy; Steven Shea | Zendy; Gregory L. Burke | Zendy; David R. Jacobs | Zendy; Stephen S. Rich | Zendy; James E. Hixson | Zendy; James H. Stein | Zendy; Hendrik G. Stunnenberg | Zendy; R. Graham Barr | Zendy; Joel D. Kaufman | Zendy; Wendy S. Post | Zendy; Ina Hoeschele | Zendy; David M. Herrington | Zendy; Douglas A. Bell | Zendy; Yongmei Liu | Zendy

Open Access

DNA Methylation of the Aryl Hydrocarbon Receptor Repressor Associations With Cigarette Smoking and Subclinical Atherosclerosis

Author(s) -

Lindsay M. Reynolds,

Ma Wan,

Jingzhong Ding,

Jackson Taylor,

Kurt Lohman,

Dan Su,

Brian D. Bennett,

Devin K. Porter,

Ryan C. Gimple,

Gary S. Pittman,

Xuting Wang,

Timothy D. Howard,

David S. Siscovick,

Bruce M. Psaty,

Steven Shea,

Gregory L. Burke,

David R. Jacobs,

Stephen S. Rich,

James E. Hixson,

James H. Stein,

Hendrik G. Stunnenberg,

R. Graham Barr,

Joel D. Kaufman,

Wendy S. Post,

Ina Hoeschele,

David M. Herrington,

Douglas A. Bell,

Yongmei Liu

Publication year - 2015

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.115.001097

Subject(s) - dna methylation , aryl hydrocarbon receptor , methylation , cotinine , biomarker , aryl hydrocarbon receptor nuclear translocator , biology , medicine , chemistry , gene , endocrinology , gene expression , genetics , nicotine , transcription factor

Tobacco smoke contains numerous agonists of the aryl hydrocarbon receptor (AhR) pathway, and activation of the AhR pathway was shown to promote atherosclerosis in mice. Intriguingly, cigarette smoking is most strongly and robustly associated with DNA modifications to an AhR pathway gene, the AhR repressor (AHRR). We hypothesized that altered AHRR methylation in monocytes, a cell type sensitive to cigarette smoking and involved in atherogenesis, may be a part of the biological link between cigarette smoking and atherosclerosis.

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