Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein–Related Measures | Zendy

Audrey Y. Chu | Zendy; Franco Giulianini | Zendy; Bryan J. Barratt | Zendy; Bo Ding | Zendy; Fredrik Nyberg | Zendy; Samia Mora | Zendy; Paul M. Ridker | Zendy; Daniel I. Chasman | Zendy

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Differential Genetic Effects on Statin-Induced Changes Across Low-Density Lipoprotein–Related Measures

Author(s) -

Audrey Y. Chu,

Franco Giulianini,

Bryan J. Barratt,

Bo Ding,

Fredrik Nyberg,

Samia Mora,

Paul M. Ridker,

Daniel I. Chasman

Publication year - 2015

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.114.000962

Subject(s) - rosuvastatin , statin , apolipoprotein b , medicine , cholesterol , single nucleotide polymorphism , lipoprotein , endocrinology , low density lipoprotein , biology , genetics , genotype , gene

Statin therapy influences not only low-density lipoprotein (LDL) cholesterol levels but also LDL-related biomarkers, including non-high-density lipoprotein cholesterol (non-HDL-C), apolipoprotein B, total number of LDL particles, and mean LDL particle size. Recent studies have identified many genetic loci influencing circulating lipid levels and statin-induced LDL cholesterol reduction. However, it is unknown how these genetic variants influence statin-induced changes in LDL subfractions and non-HDL-C.

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