Open AccessGenome-Wide Association Analysis of Plasma B–Type Natriuretic Peptide in Blacks
Author(s) -
Solomon K. Musani,
Ervin R. Fox,
Aldi T. Kraja,
Aurelian Bidulescu,
Wolfgang Lieb,
Honghuang Lin,
Ashley Beecham,
MingHuei Chen,
Janine F. Felix,
Caroline S. Fox,
W.H. Linda Kao,
Sharon L.R. Kardia,
Yongmei Liu,
Mike A. Nalls,
Tatjana Rundek,
Ralph L. Sacco,
Jennifer A. Smith,
Yan V. Sun,
Gregory Wilson,
Zhaogong Zhang,
Thomas H. Mosley,
Herman A. Taylor,
Ramachandran S. Vasan
Publication year - 2015
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.114.000900
Subject(s) - population stratification , genome wide association study , single nucleotide polymorphism , genetic association , 1000 genomes project , locus (genetics) , allele , confounding , genetics , natriuretic peptide , medicine , population , biology , gene , genotype , heart failure , environmental health
Numerous experimental studies suggest that B-type natriuretic peptide (BNP) is cardioprotective; however, in clinical studies, higher plasma BNP concentrations have been associated with incident cardiovascular disease and higher left ventricular mass. Genetic association studies may allow us to determine the true causal directions without confounding by compensatory mechanisms.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom