DNA Methylation of Lipid-Related Genes Affects Blood Lipid Levels | Zendy

Liliane Pfeiffer | Zendy; Simone Wahl | Zendy; Luke C. Pilling | Zendy; Eva Reischl | Zendy; Johanna K. Sandling | Zendy; Sonja Kunze | Zendy; Lesca M. Holdt | Zendy; Anja Kretschmer | Zendy; Katharina Schramm | Zendy; Jerzy Adamski | Zendy; Norman Klopp | Zendy; Thomas Illig | Zendy; Åsa K. Hedman | Zendy; Michael Roden | Zendy; Dena Hernández | Zendy; Andrew Singleton | Zendy; Wolfgang E. Thasler | Zendy; Harald Grallert | Zendy; Christian Gieger | Zendy; Christian Herder | Zendy; Daniel Teupser | Zendy; Christa Meisinger | Zendy; Timothy D. Spector | Zendy; Florian Kronenberg | Zendy; Holger Prokisch | Zendy; David Melzer | Zendy; Annette Peters | Zendy; Panos Deloukas | Zendy; Luigi Ferrucci | Zendy; Mélanie Waldenberger | Zendy

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DNA Methylation of Lipid-Related Genes Affects Blood Lipid Levels

Author(s) -

Liliane Pfeiffer,

Simone Wahl,

Luke C. Pilling,

Eva Reischl,

Johanna K. Sandling,

Sonja Kunze,

Lesca M. Holdt,

Anja Kretschmer,

Katharina Schramm,

Jerzy Adamski,

Norman Klopp,

Thomas Illig,

Åsa K. Hedman,

Michael Roden,

Dena Hernández,

Andrew Singleton,

Wolfgang E. Thasler,

Harald Grallert,

Christian Gieger,

Christian Herder,

Daniel Teupser,

Christa Meisinger,

Timothy D. Spector,

Florian Kronenberg,

Holger Prokisch,

David Melzer,

Annette Peters,

Panos Deloukas,

Luigi Ferrucci,

Mélanie Waldenberger

Publication year - 2015

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.114.000804

Subject(s) - dna methylation , epigenetics , methylation , methylated dna immunoprecipitation , triglyceride , medicine , cpg site , endocrinology , biology , cholesterol , genetics , gene , gene expression

Epigenetic mechanisms might be involved in the regulation of interindividual lipid level variability and thus may contribute to the cardiovascular risk profile. The aim of this study was to investigate the association between genome-wide DNA methylation and blood lipid levels high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, triglycerides, and total cholesterol. Observed DNA methylation changes were also further analyzed to examine their relationship with previous hospitalized myocardial infarction.

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