Open AccessPLA2G10 Gene Variants, sPLA2 Activity, and Coronary Heart Disease Risk
Author(s) -
Montse Guardiola,
Holly Exeter,
Claire Perret,
Lasse Folkersen,
Ferdinand van’t Hooft,
Per Eriksson,
Anders FrancoCereceda,
Gabrielle PaulssonBerne,
Jutta Palmen,
KaWah Li,
Jackie A. Cooper,
KayTee Khaw,
Ziad Mallat,
Ewa Ninio,
SoniaAthina Karabina,
Steve E. Humphries,
S. Matthijs Boekholdt,
Michael V. Holmes,
Philippa J. Talmud
Publication year - 2015
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-3268
pISSN - 1942-325X
DOI - 10.1161/circgenetics.114.000633
Subject(s) - coronary heart disease , medicine , disease , cardiology , framingham risk score
Observational studies report that secretory phospholipase A2 (sPLA2) activity is a marker for coronary heart disease (CHD) risk, and activity measures are thought to represent the composite activity of sPLA2-IIA, -V, and -X. The aim of this study was to use genetic variants of PLA2G10, encoding sPLA2-X, to investigate the contribution of sPLA2-X to the measure of sPLA2 activity and coronary heart disease (CHD) risk traits and outcome.
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