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J-wave ECG patterns are associated with an increased risk of sudden arrhythmic death, and experimental evidence supports a transient outward current (I(to))-mediated mechanism of J-wave formation. This study aimed to determine the frequency of genetic mutations in genes encoding the I(to) in patients with J waves on ECG.

circulation. cardiovascular genetics

Evaluation of Genes Encoding for the Transient Outward Current (Ito) Identifies the <i>KCND2</i> Gene as a Cause of J-Wave Syndrome Associated With Sudden Cardiac Death

Evaluation of Genes Encoding for the Transient Outward Current (Ito) Identifies the KCND2 Gene as a Cause of J-Wave Syndrome Associated With Sudden Cardiac Death