Evaluation of Genes Encoding for the Transient Outward Current (Ito) Identifies the KCND2 Gene as a Cause of J-Wave Syndrome Associated With Sudden Cardiac Death | Zendy

Mark J. Perrin | Zendy; Ar Adler | Zendy; Sharon Green | Zendy; Foad Alzoughool | Zendy; Petro Doroshenko | Zendy; Nathan Orr | Zendy; Shaheen Uppal | Zendy; Jeff S. Healey | Zendy; David H. Birnie | Zendy; Shubhayan Sanatani | Zendy; Martin J. Gardner | Zendy; Jean Champagne | Zendy; Chris Simpson | Zendy; Kamran Ahmad | Zendy; Maarten P. van den Berg | Zendy; Vijay S. Chauhan | Zendy; Peter H. Backx | Zendy; J. Peter van Tintelen | Zendy; Andrew D. Krahn | Zendy; Michael H. Gollob | Zendy

Open Access

Evaluation of Genes Encoding for the Transient Outward Current (Ito) Identifies the KCND2 Gene as a Cause of J-Wave Syndrome Associated With Sudden Cardiac Death

Author(s) -

Mark J. Perrin,

Ar Adler,

Sharon Green,

Foad Alzoughool,

Petro Doroshenko,

Nathan Orr,

Shaheen Uppal,

Jeff S. Healey,

David H. Birnie,

Shubhayan Sanatani,

Martin J. Gardner,

Jean Champagne,

Chris Simpson,

Kamran Ahmad,

Maarten P. van den Berg,

Vijay S. Chauhan,

Peter H. Backx,

J. Peter van Tintelen,

Andrew D. Krahn,

Michael H. Gollob

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.114.000623

Subject(s) - brugada syndrome , sudden cardiac death , mutation , sudden death , medicine , gene , cardiology , cardiac transient outward potassium current , j wave , genetics , biology , electrophysiology , patch clamp

J-wave ECG patterns are associated with an increased risk of sudden arrhythmic death, and experimental evidence supports a transient outward current (I(to))-mediated mechanism of J-wave formation. This study aimed to determine the frequency of genetic mutations in genes encoding the I(to) in patients with J waves on ECG.

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