Open AccessSORT1 Protective Allele Is Associated With Attenuated Postprandial
Author(s) -
Kimberly Connors,
Angela E. Karlos,
Elizabeth A. Gnatiuk,
Jane Shearer,
Raylene A. Reimer,
Dustin S. Hittel
Publication year - 2014
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.114.000534
Subject(s) - postprandial , medicine , endocrinology , chylomicron , allele , minor allele frequency , meal , lipoprotein , genotype , triglyceride , locus (genetics) , cholesterol , allele frequency , chemistry , biology , genetics , very low density lipoprotein , gene , insulin
Elevated levels of lipids and lipoproteins have strong genetic determinants and are recognized as key risk factors for atherogenesis and cardiovascular disease, particularly in the postprandial state. The aim of the study to determine whether young adults, when stratified by genotype at the rs646776 variant of the 1p13 locus, displayed differential postprandial responses to an oral fat tolerance test.
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