Open AccessSerum Lipid Levels, Body Mass Index, and Their Role in Coronary Artery Calcification
Author(s) -
Jessica van Setten,
Ivana Išgum,
Sonali Pechlivanis,
Vinicius Tragante,
Pim A. de Jong,
Joanna Smolonska,
Mathieu Platteel,
Per Hoffmann,
Matthijs Oudkerk,
Harry J. de Koning,
Markus M. Nöthen,
Susanne Moebus,
Raimund Erbel,
KarlHeinz Jöckel,
Max A. Viergever,
Willem P.Th.M. Mali,
Paul I. W. de Bakker
Publication year - 2015
Publication title -
circulation. cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.114.000496
Subject(s) - body mass index , medicine , coronary artery disease , cardiology , myocardial infarction , single nucleotide polymorphism , genotype , biology , genetics , gene
Coronary artery calcification (CAC) is widely regarded as a cumulative lifetime measure of atherosclerosis, but it remains unclear what is the relationship between calcification and traditional risk factors for coronary artery disease (CAD) and myocardial infarction (MI). This study characterizes the genetic architecture of CAC by evaluating the overall impact of common alleles associated with CAD/MI and its traditional risk factors.