Open AccessCardiac Energetic Impairment in Heart Disease and the Potential Role of Metabolic Modulators
Author(s) -
Satnam Singh,
Konstantin Schwarz,
John D. Horowitz,
Michael Frenneaux
Publication year - 2014
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.114.000221
Subject(s) - medicine , heart disease , cardiac muscle , disease , cardiology , cardiovascular physiology , bioinformatics , biology
Cardiac energetic impairment is a frequent finding in patients with both inherited and acquired diseases of heart muscle. In this review the mechanisms of energy generation in the healthy heart and their disturbances in heart muscle diseases are described. Therapeutic agents targeted at correcting cardiac energetic impairment are discussed.
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