GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function | Zendy

Fang Liu | Zendy; Min Lü | Zendy; Neil N. Patel | Zendy; Kurt J. Schillinger | Zendy; Tao Wang | Zendy; Vickas V. Patel | Zendy

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GATA-Binding Factor 6 Contributes to Atrioventricular Node Development and Function

Author(s) -

Fang Liu,

Min Lü,

Neil N. Patel,

Kurt J. Schillinger,

Tao Wang,

Vickas V. Patel

Publication year - 2015

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000587

Subject(s) - gata6 , gata4 , zinc finger , heart development , zinc finger transcription factor , transcription factor , myocyte , biology , microbiology and biotechnology , medicine , embryonic stem cell , genetics , gene

Several transcription factors regulate cardiac conduction system (CCS) development and function but the role of each in specifying distinct CCS components remains unclear. GATA-binding factor 6 (GATA6) is a zinc-finger transcription factor that is critical for patterning the cardiovascular system. However, the role of GATA6 in the embryonic heart and CCS has never been shown.

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