Association Between Shortened Leukocyte Telomere Length and Cardiometabolic Outcomes | Zendy

Matthew J.J. D’Mello | Zendy; Stephanie Ross | Zendy; Matthias Briel | Zendy; Sonia S. Anand | Zendy; Hertzel C. Gerstein | Zendy; Guillaume Paré | Zendy

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Association Between Shortened Leukocyte Telomere Length and Cardiometabolic Outcomes

Author(s) -

Matthew J.J. D’Mello,

Stephanie Ross,

Matthias Briel,

Sonia S. Anand,

Hertzel C. Gerstein,

Guillaume Paré

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000485

Subject(s) - odds ratio , medicine , confidence interval , diabetes mellitus , myocardial infarction , type 2 diabetes , meta analysis , oncology , bioinformatics , endocrinology , biology

Telomeres are repetitive, gene-poor regions that cap the ends of DNA and help maintain chromosomal integrity. Their shortening is caused by inflammation and oxidative stress within the cellular environment and ultimately leads to cellular senescence. Shortened leukocyte telomere length is hypothesized to be a novel biomarker for age and age-related diseases, yet reports on its association with cardiometabolic outcomes in the literature are conflicting.

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