Is a Diabetes Mellitus–Linked Amino Acid Signature Associated With β-Blocker–Induced Impaired Fasting Glucose? | Zendy

Rhonda M. CooperDeHoff | Zendy; Wei Hou | Zendy; Liming Weng | Zendy; Rebecca Baillie | Zendy; Amber L. Beitelshees | Zendy; Yan Gong | Zendy; Mohamed H. Shahin | Zendy; Stephen T. Turner | Zendy; Arlene B. Chapman | Zendy; John G. Gums | Zendy; Stephen H. Boyle | Zendy; Hongjie Zhu | Zendy; William R. Wikoff | Zendy; Eric Boerwinkle | Zendy; Oliver Fiehn | Zendy; Reginald F. Frye | Zendy; Rima KaddurahDaouk | Zendy; Julie A. Johnson | Zendy

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Is a Diabetes Mellitus–Linked Amino Acid Signature Associated With β-Blocker–Induced Impaired Fasting Glucose?

Author(s) -

Rhonda M. CooperDeHoff,

Wei Hou,

Liming Weng,

Rebecca Baillie,

Amber L. Beitelshees,

Yan Gong,

Mohamed H. Shahin,

Stephen T. Turner,

Arlene B. Chapman,

John G. Gums,

Stephen H. Boyle,

Hongjie Zhu,

William R. Wikoff,

Eric Boerwinkle,

Oliver Fiehn,

Reginald F. Frye,

Rima KaddurahDaouk,

Julie A. Johnson

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000421

Subject(s) - valine , medicine , phenylalanine , impaired fasting glucose , endocrinology , diabetes mellitus , isoleucine , leucine , pharmacology , insulin resistance , chemistry , amino acid , biochemistry , impaired glucose tolerance

The 5-amino acid (AA) signature, including isoleucine, leucine, valine, tyrosine, and phenylalanine, has been associated with incident diabetes mellitus and insulin resistance. We investigated whether this same AA signature, single-nucleotide polymorphisms in genes in their catabolic pathway, was associated with development of impaired fasting glucose (IFG) after atenolol treatment.

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