NOS1 Methylation and Carotid Artery Intima-Media Thickness in Children | Zendy

Carrie V. Breton | Zendy; Caron Park | Zendy; Kim Siegmund | Zendy; W. James Gauderman | Zendy; Lora Whitfield-Maxwell | Zendy; Howard N. Hodis | Zendy; Ed Avol | Zendy; Frank D. Gilliland | Zendy

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NOS1 Methylation and Carotid Artery Intima-Media Thickness in Children

Author(s) -

Carrie V. Breton,

Caron Park,

Kim Siegmund,

W. James Gauderman,

Lora Whitfield-Maxwell,

Howard N. Hodis,

Ed Avol,

Frank D. Gilliland

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000320

Subject(s) - dna methylation , methylation , epigenetics , body mass index , intima media thickness , pyrosequencing , medicine , endocrinology , genetics , biology , gene , carotid arteries , gene expression

Nitric oxide (NO) plays an important role in cardiovascular health by maintaining and regulating vascular tone and blood flow. Epigenetic regulation of NO synthase (NOS), the genes responsible for NO production, may affect cardiovascular disease, including the development of atherosclerosis in children.

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