Genetic Variants in CCNB1 Associated With Differential Gene Transcription and Risk of Coronary In-Stent Restenosis | Zendy

Carlos Silvestre-Roig | Zendy; Patricia L. Fernández | Zendy; María Luisa Mansego | Zendy; Claudia M. van Tiel | Zendy; Rosa Viana | Zendy; Chiara Viviani Anselmi | Zendy; Gianluigi Condorelli | Zendy; Robbert J. de Winter | Zendy; Paula MartínFuentes | Zendy; María Solanas-Barca | Zendy; Fernando Civeira | Zendy; Amelia Focaccio | Zendy; Carlie J.M. de Vries | Zendy; Felipe Javier Chaves | Zendy; Vicente Andrés | Zendy

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Genetic Variants in CCNB1 Associated With Differential Gene Transcription and Risk of Coronary In-Stent Restenosis

Author(s) -

Carlos Silvestre-Roig,

Patricia L. Fernández,

María Luisa Mansego,

Claudia M. van Tiel,

Rosa Viana,

Chiara Viviani Anselmi,

Gianluigi Condorelli,

Robbert J. de Winter,

Paula MartínFuentes,

María Solanas-Barca,

Fernando Civeira,

Amelia Focaccio,

Carlie J.M. de Vries,

Felipe Javier Chaves,

Vicente Andrés

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000305

Subject(s) - restenosis , medicine , odds ratio , stent , confidence interval , cohort , single nucleotide polymorphism , percutaneous coronary intervention , haplotype , angioplasty , oncology , cardiology , allele , myocardial infarction , genotype , biology , genetics , gene

The development of diagnostic tools to assess restenosis risk after stent deployment may enable the intervention to be tailored to the individual patient, for example, by targeting the use of drug-eluting stent to high-risk patients, with the goal of improving safety and reducing costs. The CCNB1 gene (encoding cyclin B1) positively regulates cell proliferation, a key component of in-stent restenosis. Therefore, we hypothesized that single-nucleotide polymorphisms in CCNB1 may serve as useful tools in risk stratification for in-stent restenosis.

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