Open AccessiPS Cell–Derived Cardiogenicity is Hindered by Sustained Integration of Reprogramming Transgenes
Author(s) -
Almudena MartinezFernandez,
Timothy J. Nelson,
Santiago Reyes,
Alexey E. Alekseev,
Frank J. Secreto,
Carmen Pérez-Terzic,
Rosanna Beraldi,
HoonKi Sung,
András Nagy,
André Terzic
Publication year - 2014
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-3268
pISSN - 1942-325X
DOI - 10.1161/circgenetics.113.000298
Subject(s) - induced pluripotent stem cell , reprogramming , transgene , biology , microbiology and biotechnology , klf4 , embryonic stem cell , myosin , cell , genetics , gene
Nuclear reprogramming inculcates pluripotent capacity by which de novo tissue differentiation is enabled. Yet, introduction of ectopic reprogramming factors may desynchronize natural developmental schedules. This study aims to evaluate the effect of imposed transgene load on the cardiogenic competency of induced pluripotent stem (iPS) cells.
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom