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Secretory phospholipase A2 (sPLA2) enzymes are considered to play a role in atherosclerosis. sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V. Although observational studies show a strong association between elevated sPLA2 activity and CHD, no assay to measure sPLA2-V levels exists, and the only evidence linking the sPLA2-V isoform to atherosclerosis progression comes from animal studies. In the absence of an assay that directly quantifies sPLA2-V levels, we used PLA2G5 mRNA levels in a novel, modified Mendelian randomization approach to investigate the hypothesized causal role of sPLA2-V in coronary heart disease (CHD) pathogenesis.

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA 2 )-V Isoenzyme in Coronary Heart Disease

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA ₂ )-V Isoenzyme in Coronary Heart Disease