Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA 2 )-V Isoenzyme in Coronary Heart Disease | Zendy

Michael V. Holmes | Zendy; Holly J. Exeter | Zendy; Lasse Folkersen | Zendy; Christopher P. Nelson | Zendy; Montse Guardiola | Zendy; Jackie A. Cooper | Zendy; Reecha Sofat | Zendy; S. Matthijs Boekholdt | Zendy; KayTee Khaw | Zendy; KaWah Li | Zendy; Andrew J. Smith | Zendy; Ferdinand van’t Hooft | Zendy; Per Eriksson | Zendy; Anders FrancoCereceda | Zendy; Folkert W. Asselbergs | Zendy; Jolanda M.A. Boer | Zendy; N. Charlotte OnlandMoret | Zendy; Marten H. Hofker | Zendy; Jeanette Erdmann | Zendy; Mika Kivimäki | Zendy; Meena Kumari | Zendy; Alex P. Reiner | Zendy; Brendan J. Keating | Zendy; Steve E. Humphries | Zendy; Aroon D. Hingorani | Zendy; Ziad Mallat | Zendy; Nilesh J. Samani | Zendy; Philippa J. Talmud | Zendy

Open Access

Novel Genetic Approach to Investigate the Role of Plasma Secretory Phospholipase A2 (sPLA ₂ )-V Isoenzyme in Coronary Heart Disease

Author(s) -

Michael V. Holmes,

Holly J. Exeter,

Lasse Folkersen,

Christopher P. Nelson,

Montse Guardiola,

Jackie A. Cooper,

Reecha Sofat,

S. Matthijs Boekholdt,

KayTee Khaw,

KaWah Li,

Andrew J. Smith,

Ferdinand van’t Hooft,

Per Eriksson,

Anders FrancoCereceda,

Folkert W. Asselbergs,

Jolanda M.A. Boer,

N. Charlotte OnlandMoret,

Marten H. Hofker,

Jeanette Erdmann,

Mika Kivimäki,

Meena Kumari,

Alex P. Reiner,

Brendan J. Keating,

Steve E. Humphries,

Aroon D. Hingorani,

Ziad Mallat,

Nilesh J. Samani,

Philippa J. Talmud

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000271

Subject(s) - mendelian randomization , single nucleotide polymorphism , odds ratio , snp , allele , confidence interval , biology , medicine , pathogenesis , genotype , bioinformatics , genetics , gene , genetic variants

Secretory phospholipase A2 (sPLA2) enzymes are considered to play a role in atherosclerosis. sPLA2 activity encompasses several sPLA2 isoenzymes, including sPLA2-V. Although observational studies show a strong association between elevated sPLA2 activity and CHD, no assay to measure sPLA2-V levels exists, and the only evidence linking the sPLA2-V isoform to atherosclerosis progression comes from animal studies. In the absence of an assay that directly quantifies sPLA2-V levels, we used PLA2G5 mRNA levels in a novel, modified Mendelian randomization approach to investigate the hypothesized causal role of sPLA2-V in coronary heart disease (CHD) pathogenesis.

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