Genome-Wide Association Study of l -Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine | Zendy

Nicole Lüneburg | Zendy; Wolfgang Lieb | Zendy; Tanja Zeller | Zendy; MingHuei Chen | Zendy; Renke Maas | Zendy; Angela M. Carter | Zendy; Vanessa Xanthakis | Zendy; Nicole L. Glazer | Zendy; Edzard Schwedhelm | Zendy; Sudha Seshadri | Zendy; M. Arfan Ikram | Zendy; W.T. Longstreth | Zendy; Myriam Fornage | Zendy; Inke R. König | Zendy; Christina Loley | Zendy; Francisco Ojeda | Zendy; Arne Schillert | Zendy; Thomas J. Wang | Zendy; Heinrich Sticht | Zendy; Anja Kittel | Zendy; Jörg König | Zendy; Emelia J. Benjamin | Zendy; Lisa Sullivan | Zendy; Isabel Bernges | Zendy; Maike Anderssohn | Zendy; Andreas Ziegler | Zendy; Christian Gieger | Zendy; Thomas Illig | Zendy; Christa Meisinger | Zendy; H.Erich Wichmann | Zendy; Philipp S. Wild | Zendy; Heribert Schunkert | Zendy; Bruce M. Psaty | Zendy; Kerri L. Wiggins | Zendy; Susan R. Heckbert | Zendy; Nicholas L. Smith | Zendy; Karl J. Lackner | Zendy; Kathryn L. Lunetta | Zendy; Stefan Blankenberg | Zendy; Jeanette Erdmann | Zendy; Thomas Münzel | Zendy; Peter J. Grant | Zendy; Ramachandran S. Vasan | Zendy; Rainer H. Böger | Zendy

Open Access

Genome-Wide Association Study of l -Arginine and Dimethylarginines Reveals Novel Metabolic Pathway for Symmetric Dimethylarginine

Author(s) -

Nicole Lüneburg,

Wolfgang Lieb,

Tanja Zeller,

MingHuei Chen,

Renke Maas,

Angela M. Carter,

Vanessa Xanthakis,

Nicole L. Glazer,

Edzard Schwedhelm,

Sudha Seshadri,

M. Arfan Ikram,

W.T. Longstreth,

Myriam Fornage,

Inke R. König,

Christina Loley,

Francisco Ojeda,

Arne Schillert,

Thomas J. Wang,

Heinrich Sticht,

Anja Kittel,

Jörg König,

Emelia J. Benjamin,

Lisa Sullivan,

Isabel Bernges,

Maike Anderssohn,

Andreas Ziegler,

Christian Gieger,

Thomas Illig,

Christa Meisinger,

H.Erich Wichmann,

Philipp S. Wild,

Heribert Schunkert,

Bruce M. Psaty,

Kerri L. Wiggins,

Susan R. Heckbert,

Nicholas L. Smith,

Karl J. Lackner,

Kathryn L. Lunetta,

Stefan Blankenberg,

Jeanette Erdmann,

Thomas Münzel,

Peter J. Grant,

Ramachandran S. Vasan,

Rainer H. Böger

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000264

Subject(s) - asymmetric dimethylarginine , medicine , genetic association , genome wide association study , stroke (engine) , population , arginine , bioinformatics , endocrinology , genetics , single nucleotide polymorphism , biology , environmental health , gene , mechanical engineering , amino acid , genotype , engineering

Dimethylarginines (DMA) interfere with nitric oxide formation by inhibiting nitric oxide synthase (asymmetrical DMA [ADMA]) and l-arginine uptake into the cell (ADMA and symmetrical DMA [SDMA]). In prospective clinical studies, ADMA has been characterized as a cardiovascular risk marker, whereas SDMA is a novel marker for renal function and associated with all-cause mortality after ischemic stroke. The aim of the current study was to characterize the environmental and genetic contributions to interindividual variability of these biomarkers.

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