Pitx2 , an Atrial Fibrillation Predisposition Gene, Directly Regulates Ion Transport and Intercalated Disc Genes | Zendy

Ye Tao | Zendy; Min Zhang | Zendy; Lele Li | Zendy; Yan Bai | Zendy; Yuefang Zhou | Zendy; Anne Moon | Zendy; Henry J. Kaminski | Zendy; James F. Martin | Zendy

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Pitx2 , an Atrial Fibrillation Predisposition Gene, Directly Regulates Ion Transport and Intercalated Disc Genes

Author(s) -

Ye Tao,

Min Zhang,

Lele Li,

Yan Bai,

Yuefang Zhou,

Anne Moon,

Henry J. Kaminski,

James F. Martin

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000259

Subject(s) - gene , atrial fibrillation , genetics , biology , medicine

Pitx2 is the homeobox gene located in proximity to the human 4q25 familial atrial fibrillation (AF) locus. When deleted in the mouse germline, Pitx2 haploinsufficiency predisposes to pacing-induced AF, indicating that reduced Pitx2 promotes an arrhythmogenic substrate. Previous work focused on Pitx2 developmental functions that predispose to AF. Although Pitx2 is expressed in postnatal left atrium, it is unknown whether Pitx2 has distinct postnatal and developmental functions.

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