Pygopus Maintains Heart Function in Aging Drosophila Independently of Canonical Wnt Signaling | Zendy

Min Tang | Zendy; Wuzhou Yuan | Zendy; Xiongwei Fan | Zendy; Ming Liu | Zendy; Rolf Bodmer | Zendy; Karen Ocorr | Zendy; Xiushan Wu | Zendy

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Pygopus Maintains Heart Function in Aging Drosophila Independently of Canonical Wnt Signaling

Author(s) -

Min Tang,

Wuzhou Yuan,

Xiongwei Fan,

Ming Liu,

Rolf Bodmer,

Karen Ocorr,

Xiushan Wu

Publication year - 2013

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000253

Subject(s) - wnt signaling pathway , gene knockdown , biology , beta catenin , endocrinology , medicine , microbiology and biotechnology , cardiac function curve , signal transduction , genetics , heart failure , gene

Heart function declines with age, but the genetic factors underlying such deterioration are largely unknown. Wnt signaling is known to play a role in heart development, but it has not been shown to be important in adult heart function. We have investigated the nuclear adapter protein encoded by pygopus (pygo), which mediates canonical Wnt signaling, for roles in aging-related cardiac dysfunction.

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