The WWOX Gene Modulates High-Density Lipoprotein and Lipid Metabolism | Zendy

Iulia Iatan | Zendy; Hong Y. Choi | Zendy; Isabelle L. Ruel | Zendy; Mitsu Reddy | Zendy; Hyunsuk Kil | Zendy; Jaeho Lee | Zendy; Mohammad Abu Odeh | Zendy; Zaidoun Salah | Zendy; Muhannad AbuRemaileh | Zendy; Daphna WeissglasVolkov | Zendy; Eliikkola | Zendy; Mete Civelek | Zendy; Zuhier Awan | Zendy; Carlo M. Croce | Zendy; Rami I. Aqeilan | Zendy; Päivi Pajukanta | Zendy; C. Marcelo Aldaz | Zendy; Jacques Genest | Zendy

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The WWOX Gene Modulates High-Density Lipoprotein and Lipid Metabolism

Author(s) -

Iulia Iatan,

Hong Y. Choi,

Isabelle L. Ruel,

Mitsu Reddy,

Hyunsuk Kil,

Jaeho Lee,

Mohammad Abu Odeh,

Zaidoun Salah,

Muhannad AbuRemaileh,

Daphna WeissglasVolkov,

Eliikkola,

Mete Civelek,

Zuhier Awan,

Carlo M. Croce,

Rami I. Aqeilan,

Päivi Pajukanta,

C. Marcelo Aldaz,

Jacques Genest

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000248

Subject(s) - wwox , high density lipoprotein , lipid metabolism , microarray , endocrinology , medicine , abca1 , microarray analysis techniques , biology , lipoprotein , cholesterol , cancer research , gene , genetics , gene expression , transporter , suppressor

Low levels of high-density lipoprotein (HDL) cholesterol constitutes a major risk factor for atherosclerosis. Recent studies from our group reported a genetic association between the WW domain-containing oxidoreductase (WWOX) gene and HDL cholesterol levels. Here, through next-generation resequencing, in vivo functional studies and gene microarray analyses, we investigated the role of WWOX in HDL and lipid metabolism.

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