Open AccessGenetic Influences on Trajectories of Systolic Blood Pressure Across Childhood and Adolescence
Author(s) -
Laura D. Howe,
Priya Parmar,
Lavinia Paternoster,
Nicole M. Warrington,
John P. Kemp,
Laurent Briollais,
John P. Newnham,
Nicholas J. Timpson,
George Davey Smith,
Susan M. Ring,
David M. Evans,
Kate Tilling,
Craig E. Pennell,
Lawrence J. Beilin,
Lyle J. Palmer,
Debbie A. Lawlor
Publication year - 2013
Publication title -
circulation cardiovascular genetics
Language(s) - English
Resource type - Journals
eISSN - 1942-325X
pISSN - 1942-3268
DOI - 10.1161/circgenetics.113.000197
Subject(s) - single nucleotide polymorphism , body mass index , cohort , blood pressure , genome wide association study , allele , medicine , genetics , biology , demography , genotype , gene , sociology
Blood pressure (BP) tends to increase across childhood and adolescence, but the genetic influences on rates of BP change are not known. Potentially important genetic influences could include genetic variants identified in genome-wide association studies of adults as being associated with BP, height, and body mass index. Understanding the contribution of these genetic variants to changes in BP across childhood and adolescence could yield understanding into the life course development of cardiovascular risk.
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