Multiancestral Analysis of Inflammation-Related Genetic Variants and C-Reactive Protein in the Population Architecture Using Genomics and Epidemiology Study | Zendy

Jonathan Kocarnik | Zendy; Sarah A. Pendergrass | Zendy; Cara L. Carty | Zendy; James S. Pankow | Zendy; Fredrick R. Schumacher | Zendy; Iona Cheng | Zendy; Peter Durda | Zendy; José Luis Ambite | Zendy; Ewa Deelman | Zendy; Nancy R. Cook | Zendy; Simin Liu | Zendy; Jean WactawskiWende | Zendy; Carolyn M. Hutter | Zendy; Kristin BrownGentry | Zendy; Sarah Wilson | Zendy; Lyle G. Best | Zendy; Nathan Pankratz | Zendy; Ching-Ping Hong | Zendy; Shelley A. Cole | Zendy; V. Saroja Voruganti | Zendy; Petra Bůžková | Zendy; Neal W. Jorgensen | Zendy; Nancy S. Jenny | Zendy; Lynne R. Wilkens | Zendy; Christopher A. Haiman | Zendy; Laurence N. Kolonel | Zendy; Andrea Z. LaCroix | Zendy; Kari E. North | Zendy; Rebecca D. Jackson | Zendy; Loı̈c Le Marchand | Zendy; Lucia A. Hindorff | Zendy; Dana C. Crawford | Zendy; Myron D. Gross | Zendy; Ulrike Peters | Zendy

Open Access

Multiancestral Analysis of Inflammation-Related Genetic Variants and C-Reactive Protein in the Population Architecture Using Genomics and Epidemiology Study

Author(s) -

Jonathan Kocarnik,

Sarah A. Pendergrass,

Cara L. Carty,

James S. Pankow,

Fredrick R. Schumacher,

Iona Cheng,

Peter Durda,

José Luis Ambite,

Ewa Deelman,

Nancy R. Cook,

Simin Liu,

Jean WactawskiWende,

Carolyn M. Hutter,

Kristin BrownGentry,

Sarah Wilson,

Lyle G. Best,

Nathan Pankratz,

Ching-Ping Hong,

Shelley A. Cole,

V. Saroja Voruganti,

Petra Bůžková,

Neal W. Jorgensen,

Nancy S. Jenny,

Lynne R. Wilkens,

Christopher A. Haiman,

Laurence N. Kolonel,

Andrea Z. LaCroix,

Kari E. North,

Rebecca D. Jackson,

Loı̈c Le Marchand,

Lucia A. Hindorff,

Dana C. Crawford,

Myron D. Gross,

Ulrike Peters

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000173

Subject(s) - single nucleotide polymorphism , genome wide association study , snp , genetic association , genetic architecture , genetic epidemiology , population , genetics , ancestry informative marker , c reactive protein , medicine , biology , disease , genotype , inflammation , gene , quantitative trait locus , environmental health

C-reactive protein (CRP) is a biomarker of inflammation. Genome-wide association studies (GWAS) have identified single-nucleotide polymorphisms (SNPs) associated with CRP concentrations and inflammation-related traits such as cardiovascular disease, type 2 diabetes mellitus, and obesity. We aimed to replicate previous CRP-SNP associations, assess whether these associations generalize to additional race/ethnicity groups, and evaluate inflammation-related SNPs for a potentially pleiotropic association with CRP.

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