Association of Levels of Fasting Glucose and Insulin With Rare Variants at the Chromosome 11p11.2- MADD Locus | Zendy

Belinda K. Cornes | Zendy; Jennifer A. Brody | Zendy; Naghmeh Nikpoor | Zendy; Alanna C. Morrison | Zendy; Huan Chu Pham Dang | Zendy; Byung Soo Ahn | Zendy; Shuai Wang | Zendy; Marco Dauriz | Zendy; Joshua I. Barzilay | Zendy; Josée Dupuis | Zendy; José C. Florez | Zendy; Josef Coresh | Zendy; Richard A. Gibbs | Zendy; W.H. Linda Kao | Zendy; Yongmei Liu | Zendy; Barbara McKnight | Zendy; Donna M. Muzny | Zendy; James S. Pankow | Zendy; Jeffrey G. Reid | Zendy; Charles C. White | Zendy; Andrew D. Johnson | Zendy; Tien Yin Wong | Zendy; Bruce M. Psaty | Zendy; Eric Boerwinkle | Zendy; Jerome I. Rotter | Zendy; David S. Siscovick | Zendy; Robert Sladek | Zendy; James B. Meigs | Zendy

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Association of Levels of Fasting Glucose and Insulin With Rare Variants at the Chromosome 11p11.2- MADD Locus

Author(s) -

Belinda K. Cornes,

Jennifer A. Brody,

Naghmeh Nikpoor,

Alanna C. Morrison,

Huan Chu Pham Dang,

Byung Soo Ahn,

Shuai Wang,

Marco Dauriz,

Joshua I. Barzilay,

Josée Dupuis,

José C. Florez,

Josef Coresh,

Richard A. Gibbs,

W.H. Linda Kao,

Yongmei Liu,

Barbara McKnight,

Donna M. Muzny,

James S. Pankow,

Jeffrey G. Reid,

Charles C. White,

Andrew D. Johnson,

Tien Yin Wong,

Bruce M. Psaty,

Eric Boerwinkle,

Jerome I. Rotter,

David S. Siscovick,

Robert Sladek,

James B. Meigs

Publication year - 2014

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000169

Subject(s) - genetics , locus (genetics) , biology , genetic association , insulin , endocrinology , medicine , gene , single nucleotide polymorphism , genotype

Common variation at the 11p11.2 locus, encompassing MADD, ACP2, NR1H3, MYBPC3, and SPI1, has been associated in genome-wide association studies with fasting glucose and insulin (FI). In the Cohorts for Heart and Aging Research in Genomic Epidemiology Targeted Sequencing Study, we sequenced 5 gene regions at 11p11.2 to identify rare, potentially functional variants influencing fasting glucose or FI levels.

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