Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine | Zendy

Marcus E. Kleber | Zendy; Ilkka Seppälä | Zendy; Stefan Pilz | Zendy; Michael M. Hoffmann | Zendy; Andreas Tomaschitz | Zendy; Niku Oksala | Zendy; Emma Raitoharju | Zendy; LeoPekka Lyytikäinen | Zendy; Kari-Matti Mäkelä | Zendy; Reijo Laaksonen | Zendy; Mika Kähönen | Zendy; Olli T. Raitakari | Zendy; Jie Huang | Zendy; Katharina Kienreich | Zendy; Astrid FahrleitnerPammer | Zendy; Christiane Drechsler | Zendy; Vera Krane | Zendy; Bernhard O. Boehm | Zendy; Wolfgang Köenig | Zendy; Christoph Wanner | Zendy; Terho Lehtimäki | Zendy; Winfried März | Zendy; Andreas Meinitzer | Zendy

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Genome-Wide Association Study Identifies 3 Genomic Loci Significantly Associated With Serum Levels of Homoarginine

Author(s) -

Marcus E. Kleber,

Ilkka Seppälä,

Stefan Pilz,

Michael M. Hoffmann,

Andreas Tomaschitz,

Niku Oksala,

Emma Raitoharju,

LeoPekka Lyytikäinen,

Kari-Matti Mäkelä,

Reijo Laaksonen,

Mika Kähönen,

Olli T. Raitakari,

Jie Huang,

Katharina Kienreich,

Astrid FahrleitnerPammer,

Christiane Drechsler,

Vera Krane,

Bernhard O. Boehm,

Wolfgang Köenig,

Christoph Wanner,

Terho Lehtimäki,

Winfried März,

Andreas Meinitzer

Publication year - 2013

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000108

Subject(s) - locus (genetics) , biology , genetics , genome wide association study , single nucleotide polymorphism , genetic association , gene , endocrinology , medicine , genotype

Low serum levels of the amino acid derivative, homoarginine, have been associated with increased risk of total and cardiovascular mortality. Homoarginine deficiency may be related to renal and heart diseases, but the pathophysiologic role of homoarginine and the genetic regulation of its serum levels are largely unknown.

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