Gene Network and Proteomic Analyses of Cardiac Responses to Pathological and Physiological Stress | Zendy

Ignat Drozdov | Zendy; Athanasios Didangelos | Zendy; Xiaoke Yin | Zendy; Anna Zampetaki | Zendy; Mélanie Abonnenc | Zendy; Colin E. Murdoch | Zendy; Min Zhang | Zendy; Christos Ouzounis | Zendy; Manuel Mayr | Zendy; Sophia Tsoka | Zendy; Ajay M. Shah | Zendy

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Gene Network and Proteomic Analyses of Cardiac Responses to Pathological and Physiological Stress

Author(s) -

Ignat Drozdov,

Athanasios Didangelos,

Xiaoke Yin,

Anna Zampetaki,

Mélanie Abonnenc,

Colin E. Murdoch,

Min Zhang,

Christos Ouzounis,

Manuel Mayr,

Sophia Tsoka,

Ajay M. Shah

Publication year - 2013

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000063

Subject(s) - biology , phenotype , gene , transcriptome , computational biology , gene regulatory network , candidate gene , gene expression , gene expression profiling , in silico , pathological , interaction network , genetics , pathology , medicine

The molecular mechanisms underlying similarities and differences between physiological and pathological left ventricular hypertrophy (LVH) are of intense interest. Most previous work involved targeted analysis of individual signaling pathways or screening of transcriptomic profiles. We developed a network biology approach using genomic and proteomic data to study the molecular patterns that distinguish pathological and physiological LVH.

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