Natural Cardiogenesis-Based Template Predicts Cardiogenic Potential of Induced Pluripotent Stem Cell Lines | Zendy

Almudena MartinezFernandez | Zendy; Xing Li | Zendy; Katherine A. Hartjes | Zendy; André Terzic | Zendy; Timothy J. Nelson | Zendy

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Natural Cardiogenesis-Based Template Predicts Cardiogenic Potential of Induced Pluripotent Stem Cell Lines

Author(s) -

Almudena MartinezFernandez,

Xing Li,

Katherine A. Hartjes,

André Terzic,

Timothy J. Nelson

Publication year - 2013

Publication title -

circulation cardiovascular genetics

Language(s) - English

Resource type - Journals

eISSN - 1942-325X

pISSN - 1942-3268

DOI - 10.1161/circgenetics.113.000045

Subject(s) - induced pluripotent stem cell , biology , embryonic stem cell , klf4 , sox2 , microbiology and biotechnology , embryoid body , transcriptome , stem cell , cellular differentiation , genetics , gene expression , gene

Cardiac development is a complex process resulting in an integrated, multilineage tissue with developmental corruption in early embryogenesis leading to congenital heart disease. Interrogation of individual genes has provided the backbone for cardiac developmental biology, yet a comprehensive transcriptome derived from natural cardiogenesis is required to gauge innate developmental milestones.

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